Immunocytochemical localization of the main intrinsic polypeptide (MIP) in ultrathin frozen sections of rat lens.

The in situ distribution of the 26-kdalton Main Intrinsic Polypeptide (MIP or MP 26), a putative gap junction protein in ocular lens fibers, was defined at the electron microscope level using indirect immunoferritin labeling of ultrathin frozen sections of rat lens. MIP was found distributed throughout the plasma membrane of the lens fiber cell, with no apparent distinction between junctional and nonjunctional membrane. MIP was not detectable in the basal or lateral plasma membrane of the lens epithelial cell, including the interepithelial cell gap junctions; nor was MIP detectable in the plasma membrane or gap junctions of the hepatocyte. Previous reports have indicated that the protein composition of the lens fiber cell junction differs from that of the hepatocyte gap junction. The evidence presented here suggests that the composition of the fiber cell junction and plasma membrane is also immunocytochemically distinct from that of its progenitor, the lens epithelial cell

Engineering report. Part 3: NASA lightweight wheel and brake sub-system. Lightweight brake development

The development of light weight wheel and brake systems designed to meet the space shuttle type requirements was investigated. The study includes the use of carbon graphite composite and beryllium as heat sink materials and the compatibility of these heat sink materials with the other structural components of the wheel and brake

Earnings distribution, corporate governance and CEO pay

We investigate the relationship between earnings differentials and the pay of CEOs of 190 British companies between 1970 and 1990. We find that (i) changes in the differential between the 90th and 50th weekly earnings percentiles for non-manual adult male workers [90:50] explain changes in the level of real CEO salary and bonus in our sample of companies; (ii) changes in this differential also account for changes in the elasticity of CEO pay to firm size; (iii) a broader measure of earnings inequality does far worse than 90:50 at explaining changes in both the level and the firm size elasticity of CEO pay; (iv) fitting the model on data for 1970-1983 and predicting pay levels for the period starting with the widespread adoption of executive share option schemes in 1984, we find a structural break in the relationship between lower management pay differentials and the pay of the CEO. We conclude first that top executive pay prior to 1984 was a stable function of both firm size and earnings differentials lower on the administrative ladder, consistent with a hypothesis advanced by Herbert Simon in 1957; and second that the use of share options from 1984 onward represents not simply a change in the mode of top executive compensation, but a de -linking of the pay of top executives and that of their subordinates

NBSymple, a double parallel, symplectic N-body code running on Graphic Processing Units

We present and discuss the characteristics and performances, both in term of computational speed and precision, of a numerical code which numerically integrates the equation of motions of N 'particles' interacting via Newtonian gravitation and move in an external galactic smooth field. The force evaluation on every particle is done by mean of direct summation of the contribution of all the other system's particle, avoiding truncation error. The time integration is done with second-order and sixth-order symplectic schemes. The code, NBSymple, has been parallelized twice, by mean of the Computer Unified Device Architecture to make the all-pair force evaluation as fast as possible on high-performance Graphic Processing Units NVIDIA TESLA C 1060, while the O(N) computations are distributed on various CPUs by mean of OpenMP Application Program. The code works both in single precision floating point arithmetics or in double precision. The use of single precision allows the use at best of the GPU performances but, of course, limits the precision of simulation in some critical situations. We find a good compromise in using a software reconstruction of double precision for those variables that are most critical for the overall precision of the code. The code is available on the web site astrowww.phys.uniroma1.it/dolcetta/nbsymple.htmlComment: Paper composed by 29 pages, including 9 figures. Submitted to New Astronomy

Restoring Aspen Riparian Stands With Beaver on the Northern Yellowstone Winter Range

Aspen (Populus tremuloides) on the Gardiner Ranger District, Gallatin National Forest, have declined over the last half-century. In an attempt to reverse this trend, beaver (Castor canadensis) were reintroduced in Eagle Creek in 1991. In 2005, we assessed the long-term effects of beaver on aspen stands and the associated riparian area in the Eagle Creek drainage. Aspen recovery was estimated by comparing vegetative changes among control sites with \u3c10 percent beaver use\u3e(n = 5), active beaver sites (n = 6), sites abandoned for 1 to 3 years (n = 7), sites abandoned for 4 to 6 years (n = 4), and sites abandoned for 7 to 11 years (n = 5). Aspen stem densities in active sites and sites abandoned by beaver for 1 to 3 years were similar (2.6/m2) and greater (P = 0.01) than the remaining sites. Sprout and sapling densities were greater (P = 0.01) on active and sites abandoned for 1 to 3 years compared to the other sites. Aspen suckers were not able to grow taller than 2m on sites without beaver activity for 4 to 1 years, which prevented aspen recovery. Beaver activity stimulated the growth of aspen sprouts and saplings, but ungulate herbivory prevented successful aspen recovery in Eagle Creek

Phase transition between d-wave and anisotropic s-wave gaps in high temperature oxides superconductors

We study models for superconductivity with two interactions: $V^>$ due to antiferromagnetic(AF) fluctuations and $V^<$ due to phonons, in a weak coupling approach to the high temperature superconductivity. The nature of the two interactions are considerably different; $V^>$ is positive and sharply peaked at ($\pm\pi$,$\pm\pi$) while $V^<$ is negative and peaked at ($0,0$) due to weak phonon screening. We numerically find (a) weak BCS attraction is enough to have high critical temperature if a van Hove anomaly is at work, (b) $V^>$ (AF) is important to give d-wave superconductivity, (c) the gap order parameter $\Delta({\bf k})$ is constant(s-wave) at extremely overdope region and it changes to anisotropic s-wave as doping is reduced, (d) there exists a first order phase transition between d-wave and anisotropic s-wave gaps. These results are qualitatively in agreement with preceding works; they should be modified in the strongly underdope region by the presence of antiferromagnetic fluctuations and ensuing AF pseudogap.Comment: 4 pages in RevTex (double column), 4 figure

Secondary Metabolic Gene Cluster Silencing in Aspergillus Nidulans

In contrast to most primary metabolism genes, the genes involved in secondary metabolism and certain nutrient utilization pathways are clustered in fungi. Recently a nuclear protein, LaeA, was found to be required for the transcription of several secondary metabolite gene clusters in Aspergillus nidulans. Here we show that LaeA regulation does not extend to nutrient utilization or the spoC1 sporulation clusters. One of the secondary metabolite clusters regulated by LaeA contains the positive regulatory (i.e. aflR) and biosynthetic genes required for biosynthesis of sterigmatocystin (ST), a carcinogenic toxin. Analysis of ST gene cluster expression indicates LaeA regulation of the cluster is location specific as transcription of genes bordering the ST cluster are unaffected in a ΔlaeA mutant and placement of a primary metabolic gene, argB, in the ST cluster resulted in argB silencing in the ΔlaeA background. ST cluster gene expression was remediated when an additional copy of aflR was placed outside of the cluster but not when placed in the cluster. Site-specific mutation of an s-adenosyl methionine (AdoMet) binding site in LaeA generated a ΔlaeA phenotype suggesting the protein to be a methyltransferase